Digital Media Image of Business University Professor

Digitalization of business and society inevitably affects almost all spheres, and education is not an exception. New high-tech tools and solutions are rapidly coming into this industry, without which further development and implementation of the educational process is no longer possible. Today target audience of any educational organizations is informationally advanced and prefers to source useful information from social networks, often making business decisions based on it. Such conditions put forward new requirements for educational organizations to increase their activity in social networks and, above all, to form a digital image. Professors are the face of any educational organization. Inasmuch as they are the subjects who directly interact with students, their personal digital image plays an important role in shaping corporate image of the university. Relevance of this article is in the research of the digital image process formation by professors of business universities, which are the flagships and market-oriented subjects of local higher education.The article aims to identify the current state of forming the digital image of teachers of entrepreneurial universities in social networks. To achieve the goal, the article discusses the features of an entrepreneurial university and the characteristics of its corporate image, shows the need to form a teacher’s digital image and identifies strategies for such formation in social networks. The study of the activity of Russian entrepreneurial universities’ teachers in social networks was carried out and the comparison of the results with the similar activity of foreign universities’ teachers was made

Magnetospheric convection from Cluster EDI measurements compared with the ground-based ionospheric convection model IZMEM

Cluster/EDI electron drift observations above the Northern and Southern polar cap areas for more than seven and a half years (2001–2008) have been used to derive a statistical model of the high-latitude electric potential distribution for summer conditions. Based on potential pattern for different orientations of the interplanetary magnetic field (IMF) in the GSM y-z-plane, basic convection pattern (BCP) were derived, that represent the main characteristics of the electric potential distribution in dependence on the IMF. The BCPs comprise the IMF-independent potential distribution as well as patterns, which describe the dependence on positive and negative IMF<I>B<sub>z</sub></I> and IMF<I>B<sub>y</sub></I> variations. The full set of BCPs allows to describe the spatial and temporal variation of the high-latitude electric potential (ionospheric convection) for any solar wind IMF condition near the Earth's magnetopause within reasonable ranges. The comparison of the Cluster/EDI model with the IZMEM ionospheric convection model, which was derived from ground-based magnetometer observations, shows a good agreement of the basic patterns and its variation with the IMF. According to the statistical models, there is a two-cell antisunward convection within the polar cap for northward IMF<I>B<sub>z</sub></I>+≤2 nT, while for increasing northward IMF<I>B<sub>z</sub></I>+ there appears a region of sunward convection within the high-latitude daytime sector, which assumes the form of two additional cells with sunward convection between them for IMF<I>B<sub>z</sub></I>+≈4–5 nT. This results in a four-cell convection pattern of the high-latitude convection. In dependence of the ±IMF<I>B<sub>y</sub></I> contribution during sufficiently strong northward IMF<I>B<sub>z</sub></I> conditions, a transformation to three-cell convection patterns takes place

Blue lupin (Lupinus angustifolius L.) ‒ the results of varieties and accessions study according to adaptivity and a set of commercialbiological traits

Cultivation of grain legumes including blue lupin (Lupinus angustifolius L.) is an important reserve for increase of high protein feed production. The aim of the research is to find perspective blue lupin varieties and accessions according to yield, adaptivity, the duration of vegetation period and biochemical indices in south-western area of the Central part of Russia. In 2019-2021 six blue lupin varieties and four accessions developed in the All-Russian Lupin Scientific Research Institute have been tested in competitive variety trial (Vityas was standard variety). The trials were laid on sod-podzolic, loamy soil with the moderate fertility level. The average grain yield of varieties in the trial was 2.07 t/ha, of standard variety – 1.85 t/ha. The varieties Bryansky kormovoy, Uzkolistny 53 and accessions BSv 51-19, USN 53-236 and SBS 56-15 had the highest grain yield. Their grain productivity varied from 2.17 to 2.29 t/ha. Statistically significant increase to the standard was 0.32-0.44 t/ha. The accessions BSv 51-19 and USN 53-236 had the maximum grain yield by adaptivity coefficient of 110%. According to the green mass yield and adaptivity Bryansky kormovoy and new promising accessions SBS 56-15, USN 53-236 and BSv 51-19 have been noted: the increase to the standard according to the green mass yield was 5.0-7.0 t/ha, the adaptivity coefficient was 104-110%. By the duration of vegetation period (80-89 days) all varieties and accessions were included into the group of early-ripening. The new tall variety Belorozovy 144 had the longest vegetation period (89 days). According to the alkaloid content in the grain (0.031-0.063 %) all tested varieties and accessions were included into the low-alkaloid group. The varieties Smena, Uzkolistny 53 and the accession SBS 56-15 were characterized by stable low index (0.031-0.039 %). The content of raw protein in the seeds of tested varieties and accessions of blue lupin varied in the range of 32.0-33.8%. According to the set of positive traits, Bryansky kormovoy variety and accessions USN 53-236 and SBS 56-15 have been noted

СТАН БІОЦЕНОЗУ ПІХВИ ВАГІТНИХ З АНТЕНАТАЛЬНОЮ ЗАГИБЕЛЛЮ ПЛОДА

The aim of study – to learn the microbial biocenosis of the vagina with antenatal loss of the fetus.Materials and Methods. We examined 55 women, 30 of whom with antenatal death of fetus (АDF, principle group) and 25 women with live childbirth (control group), comparable in age, parity, somatic pathology with the main group. The study of infectious status included: microscopic examination of vaginal smears; bacteriological culture on the flora of the contents of the cervical canal; PCR diagnostics of the contents of the cervical canal, bacteriological culture of urine.Results and Discussion. The analysis showed that among women with AFD the incidence rate (number of diseases per person) was 0.77 or 76.7 ± 4.3 %, this is 2.4 times more than in the pregnant control group (morbidity rate 0.32 or 32 ± 3.1 %, p <0.05). A frequent complication of the first half of pregnancy was early gestosis, menacing abortion, anemia (p <0.05). The level of infection in the main group was 2.6 times higher than in the control group (p <0.05). All women with vaginal infection were treated. It should be noted that during pregnancy, infection is often characterized by an asymptomatic course and frequent relapses, which may be due to changes in the hormonal balance, the presence of an immunosuppression factor associated with globulins in the serum.Concluions. In pregnant women with AFD, the peincipal risk factors for intrauterine infection of the fetus are urogenital infections of mother, chronic foci of infection in the woman's body, their aggravation during pregnancy, infectious diseases during gestation. It is necessary to make attention to the presence of a burdened obstetric-gynecological history. Activation of opportunistic flora and prolonged exposure to an infectious agent contribute to the development of immune disorders, which in turn exacerbate the dysbiotic state, thereby supporting the inflammatory process and significantly increasing the risk of intrauterine infection of the fetus until its antenatal death.Цель исследования – изучение микробного биоценоза влагалища беременных при антенатальной гибели плода.Материалы и методы. Обследовано 55 женщин, из них 30 женщин с антенатальной гибелью плода (АГП, основная группа) и 25 женщин с рождением живых детей (контрольная группа), сопоставимых по возрасту, паритету, соматической патологии. Исследование инфекционного статуса включало: микроскопическое исследование влагалищных мазков; бактериологический посев на флору содержимого цервикального канала; ПЦР-диагностику содержимого цервикального канала.Результаты исследования и их обсуждение. Проведенный анализ показал, что среди женщин с АГП коэффициент заболеваемости (число заболеваний на одного человека) составил 0,77 или (76,7±4,3) %, это в 2,4 раза выше, чем у беременных контрольной группы (коэффициент заболеваемости 0,32 или (32±3,1) %, р<0,05). Достоверно чаще у пациенток основной группы беременность сопровождалась ранними и поздними гестозами, угрожающим абортом, анемией (р<0,05). Уровень инфицирования при взятии на учет в основной группе был в 2,6 раза выше, чем в контрольной (р<0,05). Всем женщинам с инфицированием влагалища была проведена санация. При поступлении в стационар при сравнении микробиоценоза цервикального канала у женщин с АГП и нормальным течением беременности выявлены значительные различияв количественном и качественном составе микрофлоры.Выводы. У беременных с АГП основными факторами риска внутриутробного инфицирования плода являются урогенитальные инфекции у матери, хронические очаги инфекции в организме женщины, их обострение во время беременности, инфекционные заболевания в период гестации, наличие отягощенного акушерско-гинекологического анамнеза. Активация условно-патогенной флоры и длительное воздействие инфекционного агента способствуют развитию иммунных нарушений, которые, в свою очередь, еще больше усугубляют дисбиотическое состояние, поддерживая тем самым воспалительныйпроцесс и значительно повышая риск внутриутробного инфицирования плода, вплоть до его антенатальной гибели.Мета дослідження. Метою нашого дослідження було вивчення мікробного біоценозу піхви вагітних з антенатальною загибеллМатеріал і методи дослідження. Обстежено 55 жінок, з них 30 жінок з антенатальною загибеллю плода (АЗП, основна група) та 25 жінок з народженням живих дітей (контрольна група), порівняних за віком, паритетом, соматичною патологією. Дослідження інфекційного статусу включало: мікроскопічне дослідження вагінальних мазків; бактеріологічний посів на флору вмісту цервікального каналу; ПЛР-діагностику вмісту цервікального каналу. Результати дослідження та їх обговорення. Проведений аналіз показав, що серед жінок з АЗП коефіцієнт захворюваності (число захворювань на одну людину) становив 0,77 або 76,7 ± 4,3%, це в 2,4 рази більше, ніж у вагітних контрольної групи (коефіцієнт захворюваності 0, 32 або 32 ± 3,1%, р <0,05). Достовірно частіше у пацієнток основної групи вагітність супроводжувалася ранніми та пізніми гестозами, загрозливим абортом, анемією (р <0,05). Рівень інфікування піхви при взятті на облік в основній групі був у2,6 рази вищим, ніж у контрольній (р <0,05). Всім жінкам з інфікуванням піхви була проведена санація. При надходженні в стаціонар при порівнянні мікробіоценозу цервікального каналу у жінок з АЗП і нормальним перебігом вагітності виявлені значні відмінності в кількісному і якісному складі мікрофлори.Висновки. У вагітних з АЗП основними факторами ризику внутрішньоутробного інфікування плода є урогенітальні інфекції у матері, хронічні вогнища інфекції в організмі жінки, їх загострення під час вагітності, інфекційні захворювання в період гестації, наявність обтяженого акушерсько-гінекологічного анамнезу. Активація умовно-патогенної флори і тривалий вплив інфекційного агента сприяють розвитку імунних порушень, які, в свою чергу, ще більше посилюють дисбіотичний стан, підтримуючи тим самим запальний процес і значно підвищуючи ризик внутрішньоутробного інфікування плода аж до його антенатальної загибелі

Gel-Based Proteomics of Clinical Samples Identifies Potential Serological Biomarkers for Early Detection of Colorectal Cancer

The burden of colorectal cancer (CRC) is considerable—approximately 1.8 million people are diagnosed each year with CRC and of these about half will succumb to the disease. In the case of CRC, there is strong evidence that an early diagnosis leads to a better prognosis, with metastatic CRC having a 5-year survival that is only slightly greater than 10% compared with up to 90% for stage I CRC. Clearly, biomarkers for the early detection of CRC would have a major clinical impact. We implemented a coherent gel-based proteomics biomarker discovery platform for the identification of clinically useful biomarkers for the early detection of CRC. Potential protein biomarkers were identified by a 2D gel-based analysis of a cohort composed of 128 CRC and site-matched normal tissue biopsies. Potential biomarkers were prioritized and assays to quantitatively measure plasma expression of the candidate biomarkers were developed. Those biomarkers that fulfilled the preset criteria for technical validity were validated in a case-control set of plasma samples, including 70 patients with CRC, adenomas, or non-cancer diseases and healthy individuals in each group. We identified 63 consistently upregulated polypeptides (factor of four-fold or more) in our proteomics analysis. We selected 10 out of these 63 upregulated polypeptides, and established assays to measure the concentration of each one of the ten biomarkers in plasma samples. Biomarker levels were analyzed in plasma samples from healthy individuals, individuals with adenomas, CRC patients, and patients with non-cancer diseases and we identified one protein, tropomyosin 3 (Tpm3) that could discriminate CRC at a significant level (p = 0.0146). Our results suggest that at least one of the identified proteins, Tpm3, could be used as a biomarker in the early detection of CRC, and further studies should provide unequivocal evidence for the real-life clinical validity and usefulness of Tpm3

Network Rewiring of Homologous Recombination Enzymes during Mitotic Proliferation and Meiosis.

Homologous recombination (HR) is essential for high-fidelity DNA repair during mitotic proliferation and meiosis. Yet, context-specific modifications must tailor the recombination machinery to avoid (mitosis) or enforce (meiosis) the formation of reciprocal exchanges-crossovers-between recombining chromosomes. To obtain molecular insight into how crossover control is achieved, we affinity purified 7 DNA-processing enzymes that channel HR intermediates into crossovers or noncrossovers from vegetative cells or cells undergoing meiosis. Using mass spectrometry, we provide a global characterization of their composition and reveal mitosis- and meiosis-specific modules in the interaction networks. Functional analyses of meiosis-specific interactors of MutLγ-Exo1 identified Rtk1, Caf120, and Chd1 as regulators of crossing-over. Chd1, which transiently associates with Exo1 at the prophase-to-metaphase I transition, enables the formation of MutLγ-dependent crossovers through its conserved ability to bind and displace nucleosomes. Thus, rewiring of the HR network, coupled to chromatin remodeling, promotes context-specific control of the recombination outcome

NEW WAY OF ISOLATION OF ENZYME COMPLEX OF CHOLERA VIBRIO - PROTEOVIBRIN BY MEANS OF ULTRAFILTRATION

The technology of isolation of the cholera vibrio complex of low-molecular enzymes related to pathogenicity factors, from cholera vaccine production wastes by means of concentrating ultrafiltration was developed. This technology allows to obtain standard series of the preparation termed proteovibrin which is free from the basic Vibrio cholerae immunogen - O-antigen, and possesses high activity of protease and. phospholipases A2 and. C. It is shown that proteovibrin is highly soluble in water and 0.14 molar NaCl solution, causes the production of antibodies in rabbits and is toxic for white mice. Its further examination seems to be promising, as well as its possible use as additional source of the cholera vibrio enzymes and. as tripsin-like preparation, applicable for protein raw material hydrolysis in production of microbiological nutrient media

Space weather and space anomalies

A large database of anomalies, registered by 220 satellites in different orbits over the period 1971-1994 has been compiled. For the first time, data from 49 Russian Kosmos satellites have been included in a statistical analysis. The database also contains a large set of daily and hourly space weather parameters. A series of statistical analyses made it possible to quantify, for different satellite orbits, space weather conditions on the days characterized by anomaly occurrences. In particular, very intense fluxes (>1000 pfu at energy >10 MeV) of solar protons are linked to anomalies registered by satellites in high-altitude (>15000 km), near-polar (inclination >55°) orbits typical for navigation satellites, such as those used in the GPS network, NAVSTAR, etc. (the rate of anomalies increases by a factor ~20), and to a much smaller extent to anomalies in geostationary orbits, (they increase by a factor ~4). Direct and indirect connections between anomaly occurrence and geomagnetic perturbations are also discussed

Specifities of menstrual cycle of women diagnosed with diabetes type 1

In this article the research is carried the course of menstruation of reproductive-age women diagnosed with diabetes type 1. Women is treated in the endocrinology department of Sverdlovsk regional clinical hospital №1, also we used online- questionnaire. In this research it is taken into account such criteria as duration of menstrual cycle, menstruation’s duration, regularity of menstruation, delay in menstruation, premature start of menstruation, volume blood, the existence of the premenstrual and pain syndrome, blood glucose level, glycated hemoglobin, years of suffering diabetes.В статье произведено исследование течения менструации у женщин репродуктивного возраста с диагнозом сахарный диабет 1 типа, которые находятся на стационарном лечении в отделении эндокринологии Свердловской областной клинической больницы №1, также было использовано онлайн-анкетирование. Во время исследования учитывались такие критерии, как: длительность менструального цикла, количество дней менструации, регулярность менструации, наличие задержки наступления менструации, преждевременного начала менструации, объем кровянистых выделений, наличие предменструального синдрома, болевой синдром во время менструации, уровень гликированного гемоглобина, глюкозы крови, стаж диабет